Nuban Institute

What Is VDR?


VDR is a gene which encodes for a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene known as rs2228570 (FokI polymorphism), is associated with decreased bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and temporal on-and-off occupancy of VDRE between the two components. It is also affected by chromosomal positioning and binding preferences for certain hormones. Microarray studies of human cells show that over 100 genes have a recognizable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) can serve as a repository of information and documents that are relevant to legal, business transactions or processes. Viewing, downloading, and printing are all restricted. It makes use of central servers and an extranet connection which is an Internet connection with restricted access, to provide controlled log-on for set times when users can browse the documents and data.

VDRs are typically used by investment banks and businesses involved in mergers or acquisitions. They require a secure platform to share information with investors or buyers in a way that is transparent and due diligence can require massive quantities of data. Life science companies also make use of VDRs for everything from clinical trials results to HIPAA compliance documents.

Leave a Comment